The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.

@article{Chen2013TheMP,
  title={The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.},
  author={Zuxin Chen and Benjamin Cooper and Stefan Kalla and Frederique Varoqueaux and Samuel M Young},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 19},
  pages={8336-51}
}
The Munc13 gene family encodes molecules located at the synaptic active zone that regulate the reliability of synapses to encode information over a wide range of frequencies in response to action potentials. In the CNS, proteins of the Munc13 family are critical in regulating neurotransmitter release and synaptic plasticity. Although Munc13-1 is essential for synaptic transmission, it is paradoxical that Munc13-2 and Munc13-3 are functionally dispensable at some synapses, although their loss in… CONTINUE READING