The Mucosal Adjuvant Activities of ADP-Ribosylating Bacterial Enterotoxins.

@article{Snider2017TheMA,
  title={The Mucosal Adjuvant Activities of ADP-Ribosylating Bacterial Enterotoxins.},
  author={Denis P. Snider},
  journal={Critical reviews in immunology},
  year={2017},
  volume={37 2-6},
  pages={499-530}
}
The bacterial enterotoxins, cholera toxin and the heat labile toxin of E. coli, are well known adjuvants for mucosal immune response. Their common A chain mediates the toxigenic mechanism by causing ADP ribosylation of G proteins and subsequent elevation of cAMP in target cells. A large IgA and IgG antibody response to admixed protein antigen (Ag) is the hallmark of these adjuvants and is clearly associated with the A chain activity. Expansion of Ag-specific B and T cells, alteration of T cell… CONTINUE READING