The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing

  title={The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing},
  author={Francesco Ortuso and Donatella Bagetta and Annalisa Maruca and Carmine Talarico and Mar{\'i}a Laura Bolognesi and Norbert Haider and Fernanda Borges and Sharon D. Bryant and Thierry Langer and Hanoch Senderowitz and Stefano Alcaro},
  journal={Frontiers in Chemistry},
For every lead compound developed in medicinal chemistry research, numerous other inactive or less active candidates are synthetized/isolated and tested. The majority of these compounds will not be selected for further development due to a sub-optimal pharmacological profile. However, some poorly active or even inactive compounds could live a second life if tested against other targets. Thus, new therapeutic opportunities could emerge and synergistic activities could be identified and exploited… 

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