The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development.

@article{Wang2011TheMH,
  title={The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development.},
  author={Jingqiang Wang and R. M. Satheesh Kumar and Vanessa J Biggs and Hansol Lee and Yun Chen and Michael H Kagey and Richard A. Young and Cory Abate-Shen},
  journal={Developmental cell},
  year={2011},
  volume={21 3},
  pages={575-88}
}
Control of gene expression during development requires the concerted action of sequence-specific transcriptional regulators and epigenetic modifiers, which are spatially coordinated within the nucleus through mechanisms that are poorly understood. Here we show that transcriptional repression by the Msx1 homeoprotein in myoblast cells requires the recruitment of Polycomb to target genes located at the nuclear periphery. Target genes repressed by Msx1 display an Msx1-dependent enrichment of… CONTINUE READING
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