The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.

  title={The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.},
  author={Ning Li and Maryam Yousefi and Angela Nakauka-Ddamba and Fan Li and Lee E. Vandivier and Kimberly Parada and D Woo and Shan Wang and Ammar S Naqvi and Shilpa J. Rao and John W Tobias and Ryan James Cedeno and Gerard Minuesa and Y Katz and Trevor S Barlowe and Alexander J. Valvezan and Sheila Shankar and Raquel P. Deering and Peter G. Klein and Shane T. Jensen and Michael G Kharas and Brian D. Gregory and Zhengquan Yu and Christopher J Lengner},
  journal={Cell reports},
  volume={13 11},
Members of the Msi family of RNA-binding proteins have recently emerged as potent oncoproteins in a range of malignancies. MSI2 is highly expressed in hematopoietic cancers, where it is required for disease maintenance. In contrast to the hematopoietic system, colorectal cancers can express both Msi family members, MSI1 and MSI2. Here, we demonstrate that, in the intestinal epithelium, Msi1 and Msi2 have analogous oncogenic effects. Further, comparison of Msi1/2-induced gene expression programs… CONTINUE READING
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