The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks.

Abstract

Mutations in components of the Mre11/Rad50/Nbs1 complex give rise to genetic disorders characterized by neurological abnormalities, radiosensitivity, cell cycle checkpoint defects, genomic instability and cancer predisposition. Evidence exists that this complex associates with chromatin during DNA replication and acts as a sensor of double strand breaks… (More)

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@article{Lavin2004TheMC, title={The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks.}, author={Martin Francis Lavin}, journal={DNA repair}, year={2004}, volume={3 11}, pages={1515-20} }