The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.

@article{Kim2017TheMI,
  title={The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.},
  author={Jun Hyun Kim and Malgorzata Grosbart and Roopesh Anand and C. Wyman and Petr Cejka and John H. J. Petrini},
  journal={Cell reports},
  year={2017},
  volume={18 2},
  pages={
          496-507
        }
}
The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal levels. To delineate essential and non-essential Mre11 complex functions that are mediated by Nbs1, we used TALEN-based genome editing to derive Nbs1 mutant mice (Nbs1mid mice), which harbor mutations in the Mre11 interaction domain of Nbs1. Nbs1mid alleles… CONTINUE READING
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