The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system.

@article{Bretl2014TheME,
  title={The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system.},
  author={Daniel J. Bretl and Tarin M Bigley and Scott S. Terhune and Thomas C. Zahrt},
  journal={Journal of bacteriology},
  year={2014},
  volume={196 2},
  pages={391-406}
}
Mycobacterium tuberculosis is an acid-fast pathogen of humans and the etiological agent of tuberculosis (TB). It is estimated that one-third of the world's population is latently (persistently) infected with M. tuberculosis. M. tuberculosis persistence is regulated, in part, by the MprAB two-component signal transduction system, which is activated by and mediates resistance to cell envelope stress. Here we identify MprAB as part of an evolutionarily conserved cell envelope stress response… CONTINUE READING