• Corpus ID: 20482615

The Most Common Drug Interactions Associated With the Serotonin Syndrome in 38 Patients in 12 Reports Reference

@inproceedings{Harvey2005TheMC,
  title={The Most Common Drug Interactions Associated With the Serotonin Syndrome in 38 Patients in 12 Reports Reference},
  author={Harvey and Sternbach},
  year={2005}
}
Objective and Method: A review of the literature on the serotonin syndrome in animals and human beings was conducted, and I 2 reports of 3 8 cases in human patients were then analyzed to determine the most frequently reported clinical features and drug interactions, as well as the incidence, treatment, and outcome of this syndrome. Findings: The serotonin syndrome is most commonly the result of the interaction between serotonergic agents and monoamine oxidase inhibitors. The most frequent… 

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SHOWING 1-10 OF 65 REFERENCES
Adverse consequences of fluoxetine-MAOI combination therapy.
The authors describe two series of patients: 12 treated simultaneously with fluoxetine and a monoamine oxidase inhibitor and 6 patients started on treatment with an MAOI 10 days or more after
[Effect of long-term lithium treatment on serotonin syndrome in rats].
TLDR
Li-induced supersensitivity of 5-HT1 receptor-mediated behaviors inconsistent with the previous reports of the down-regulation of 5.HT1 receptors measured by receptor binding assay is unexplained.
Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor
TLDR
When similar doses of tryptophan were administered to patients undergoing treatment with a potent inhibitor of monoamine oxidase (MAO), definite neurologic alterations occurred and their relationship to alterations in the metabolism oftryptamine and 5-hydroxytryptamine (serotonin).
monoamine oxidase inhibitors revisited
TLDR
A final decision on the administration of anaesthesia in the presence of MAOI therapy can only be made by an anaesthetist familiar with the pharmacology of the MAO system and its inhibitors.
Serotonin receptor and reuptake sites: pharmacologic significance.
TLDR
The increasing ability to modulate serotonergic neurotransmission via distinct serotonin (5-HT) receptor subtypes should greatly facilitate the analysis of the role of 5-HT in both normal and abnormal human brain function.
A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence.
TLDR
The electrophysiologic assessment of the action of different types of antidepressant treatments on the serotonin system revealed as a common effect an enhancement of 5-HT neurotransmission, albeit each treatment achieved this result via a different mechanism.
Central-nervous-system effects of ingestin of L-tryptophan by normal subjects.
TLDR
It is found that combined therapy with tryptophan and iproniazid had more therapeutic effect on psychotic patients than ipronsiazid alone, and administration of tryPTophan to subjects receiving monoamine oxidase inhibitors produced hyperreflexia, clonus and euphoria.
‘Neuroleptic Malignant Syndrome’ Without Neuroleptics
TLDR
It has, however, proved to be increasingly difficult, if not impossible, to find patients with depersonalisation who were not over-breathing, and the idea appears to have spread in this hospital and it has been quoted to me as ' Neuroleptic Malignant Syndrome' Without Neuroleptics.
Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan.
TLDR
The administration of 5-hydroxytryptophan to dogs, cats, rabbits, rats and mice produced somatic, autonomic and behavioral effects which grossly resembled those of lysergic acid diethylamide which suggested that 5HTP may prove useful in studying the function of serotonin.
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