The Mosquito Melanization Response Is Implicated in Defense against the Entomopathogenic Fungus Beauveria bassiana

@inproceedings{Yassine2012TheMM,
  title={The Mosquito Melanization Response Is Implicated in Defense against the Entomopathogenic Fungus Beauveria bassiana},
  author={Hassan Yassine and Layla Kamareddine and Mike Abboud Osta},
  booktitle={PLoS pathogens},
  year={2012}
}
Mosquito immunity studies have focused mainly on characterizing immune effector mechanisms elicited against parasites, bacteria and more recently, viruses. However, those elicited against entomopathogenic fungi remain poorly understood, despite the ubiquitous nature of these microorganisms and their unique invasion route that bypasses the midgut epithelium, an important immune tissue and physical barrier. Here, we used the malaria vector Anopheles gambiae as a model to investigate the role of… CONTINUE READING

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Here , we used the malaria vector Anopheles gambiae as a model to investigate the role of melanization , a potent immune effector mechanism of arthropods , in mosquito defense against the entomopathogenic fungus Beauveria bassiana , using in vivo functional genetic analysis and confocal microscopy .
Here , we used the malaria vector Anopheles gambiae as a model to investigate the role of melanization , a potent immune effector mechanism of arthropods , in mosquito defense against the entomopathogenic fungus Beauveria bassiana , using in vivo functional genetic analysis and confocal microscopy .
However , those elicited against entomopathogenic fungi remain poorly understood , despite the ubiquitous nature of these microorganisms and their unique invasion route that bypasses the midgut epithelium , an important immune tissue and physical barrier .
However , those elicited against entomopathogenic fungi remain poorly understood , despite the ubiquitous nature of these microorganisms and their unique invasion route that bypasses the midgut epithelium , an important immune tissue and physical barrier .
However , those elicited against entomopathogenic fungi remain poorly understood , despite the ubiquitous nature of these microorganisms and their unique invasion route that bypasses the midgut epithelium , an important immune tissue and physical barrier .
However , those elicited against entomopathogenic fungi remain poorly understood , despite the ubiquitous nature of these microorganisms and their unique invasion route that bypasses the midgut epithelium , an important immune tissue and physical barrier .
HyphaeNo subtypeMycelium
Nevertheless , melanin rarely aborted the growth of any of these stages and the mycelium continued growing despite being melanized . Silencing TEP1 and CLIPA8 , key positive regulators of Plasmodium and bacterial melanization in A. gambiae , abolished completely melanin formation on hyphae but not on germinating conidia or germ tubes .
MyceliumNo subtypeHyphae
Nevertheless , melanin rarely aborted the growth of any of these stages and the mycelium continued growing despite being melanized . Silencing TEP1 and CLIPA8 , key positive regulators of Plasmodium and bacterial melanization in A. gambiae , abolished completely melanin formation on hyphae but not on germinating conidia or germ tubes .
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