The Mortality Experience of Workers Exposed to 2,3,7,8‐Tetrachlorodibenzo-p-dioxin in a Trichlorophenol Process Accident

  title={The Mortality Experience of Workers Exposed to 2,3,7,8‐Tetrachlorodibenzo-p-dioxin in a Trichlorophenol Process Accident},
  author={James J. Collins and M E Strauss and George J. Levinskas and Patrick R. Conner},
Epidemiologic studies on dioxin, specifically 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD), have not consistently found an increased cancer risk. This study examines mortality rates for 754 employees at a chemical plant after an accident in 1949 in which 122 workers developed chloracne from high exposure to TCDD. We also examined exposure to 4-aminobiphenyl, a potential bladder carcinogen. Although the numbers are small, and confounding factors cannot be ruled out, workers exposed to 4… Expand
Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study.
Exposure to herbicides contaminated with TCDD and higher chlorinated dioxins may be associated with a small increase in overall cancer risk and in risk for specific cancers. Expand
Human health effects after exposure to 2,3,7,8-TCDD
Of the many non-cancer health effects thought to be associated with 2,3,7,8-TCDD exposure, only chloracne, elevations in GGT and triglyceride levels, and alterations in FSH and LH were related to serum 2, 3, 7, 8- TCDD levels. Expand
Mortality Rates Among Trichlorophenol Workers With Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
With the exception of soft tissue sarcoma, the authors found little evidence of increased disease risk from exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Expand
Mortality experience of employees exposed to 2-mercaptobenzothiazole at a chemical plant in Nitro, West Virginia.
There was an excess of bladder cancer in MBT workers who had PAB related assignments and there were no associations between exposure to MBT and increased rates of most malignant neoplasms in employees without a job assignment with exposure to PAB. Expand
Mortalities of workers at the Nitro plant with exposure to 2-mercaptobenzothialzole.
Exposure to MBT does not seem to increase the risk of most cancers including cancers of the lung and prostate, but the potential confounding of exposure to an unknown portion of PAB in the MBT workers makes it impossible to evaluate risk of bladder cancer in this population at this time. Expand
Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers.
The authors studied noncancer mortality among phenoxyacid herbicide and chlorophenol production workers and sprayers included in an international study comprising 36 cohorts from 12 countries followed from 1939 to 1992 to suggest a moderate healthy worker effect for all circulatory diseases, especially ischemic heart disease. Expand
Cause-specific mortality of Dutch chlorophenoxy herbicide manufacturing workers
The results of this study showed only slight increases in cancer mortality risk and the increased risk for urinary cancers is noteworthy, but could not be linked to a specific exposure and needs to be confirmed in similar cohorts. Expand
Tcdd Exposure-Response Analysis and Risk Assessment
The estimated incremental lifetime risk of mortality at age 75 from all cancers was about 6 to more than 10 times lower than previous estimates derived from this cohort using exposure models that did not consider the age and concentration dependence of TCDD elimination. Expand
2,3,7,8-Tetrachlorodibenzo-p-dioxin mechanistic data and risk assessment: gene regulation, cytotoxicity, enhanced cell proliferation, and tumor promotion.
Tumorigenicity by TCDD in rodents has been linked to cellular necrosis, enhanced cell proliferation and tumor promotion, and biopersistence and organ distribution may play an important role in T CDD dosage extrapolation to humans, but these have not been adequately determined. Expand
The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health.
The epidemiologic data reviewed provide no convincing evidence that organochlorines cause a large excess number of cancers, but evidence suggesting insidious effects of background exposure is of more general interest. Expand