The Morbillivirus Receptor SLAM (CD150)

@article{Tatsuo2002TheMR,
  title={The Morbillivirus Receptor SLAM (CD150)},
  author={Hironobu Tatsuo and Yusuke Yanagi},
  journal={Microbiology and Immunology},
  year={2002},
  volume={46}
}
Morbilliviruses are highly contagious pathogens that cause some of the most devastating viral diseases of humans and animals, including measles virus (MV), canine distemper virus (CDV), and rinderpest virus (RPV). They replicate mainly in lymphoid organs throughout the body and cause severe immunosuppression accompanied with lymphopenia. We have recently shown that human, canine, and bovine signaling lymphocyte activation molecules (SLAMs; also known as CD150) act as cellular receptors for MV… Expand
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TLDR
This review discusses receptor interactions, tropism, and mechanisms involved in the severe, transient immunosuppression induced by MV and other morbilliviruses. Expand
A negative search of acute canine distemper virus infection in DogSLAM transgenic C57BL/6 mice.
TLDR
The transgenic mouse is not a suitable animal model for CDV, or a longer incubation period is prerequisite, it needs to be clarified in a future study, and the evidence of CDV infection in this study could not be demonstrated in acute phase. Expand
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Experimental Adaptation of Wild-Type Canine Distemper Virus (CDV) to the Human Entry Receptor CD150
TLDR
Structural modelling suggests that the adaptive mutation D540G in H reflects the sequence alteration from canine to human CD150 at position 70 and 71 from Pro to Leu and Gly to Glu, and compensates for the gain of a negative charge in the humanCD150 molecule. Expand
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TLDR
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Immunohistochemical Demonstration of the Putative Canine Distemper Virus Receptor CD150 in Dogs with and without Distemper
TLDR
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Enhanced immunosurveillance for animal morbilliviruses using vesicular stomatitis virus (VSV) pseudotypes
TLDR
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Systemic spread of measles virus: overcoming the epithelial and endothelial barriers.
TLDR
It has been postulated (and demonstrated in macaques) that the initial infection is independent from usage of this receptor, and that the first target cells appear to be CD150-positive cells in the epithelium, and it is claimed that this unknown receptor on epithelial cells is required for crossing the barrier from within. Expand
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References

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Morbilliviruses Use Signaling Lymphocyte Activation Molecules (CD150) as Cellular Receptors
TLDR
The findings suggest that the use of SLAM as a cellular receptor may be a property common to most, if not all, morbilliviruses and explain the lymphotropism and immunosuppressive nature of morbillIViruses. Expand
Induction of the measles virus receptor SLAM (CD150) on monocytes.
TLDR
Anti-SLAM monoclonal antibodies efficiently blocked infection of activated monocytes with a wild-type strain of MV and indicate that SLAM is readily induced and acts as a monocyte receptor for MV. Expand
SLAM (CDw150) is a cellular receptor for measles virus
TLDR
It is shown that human SLAM (signalling lymphocyte-activation molecule), a recently discovered membrane glycoprotein expressed on some T and B cells, is a cellular receptor for measles virus, including the Edmonston strain. Expand
The Hemagglutinin of Canine Distemper Virus Determines Tropism and Cytopathogenicity
TLDR
The fusogenicity, growth characteristics, and tropism of the recombinant viruses were examined and compared with those of the parental strains and all these characteristics were found to be predominantly mediated by the H protein regardless of the viral backbone used. Expand
CD150 (SLAM) Is a Receptor for Measles Virus but Is Not Involved in Viral Contact-Mediated Proliferation Inhibition
TLDR
The data indicate that proliferation inhibition induced by MV contact is independent of the presence or absence of the virus-binding receptors SLAM and CD46, and the cell-type-specific expression of SLAM does not correlate with the sensitivity of cells for proliferation inhibition. Expand
The human CD46 molecule is a receptor for measles virus (Edmonston strain)
TLDR
Results prove that human CD46 permits cells both to bind measles virus and to support infection and polyclonal antisera against CD46 inhibited virus binding and infection. Expand
The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150)
TLDR
The measles virus hemagglutinin can induce downregulation of SLAM in cells either expressing or coming in contact with it. Expand
V Domain of Human SLAM (CDw150) Is Essential for Its Function as a Measles Virus Receptor
TLDR
Results indicate that the V domain of human SLAM is necessary and sufficient to interact with the MV H protein and allow MV entry. Expand
Antibodies to CD9, a Tetraspan Transmembrane Protein, Inhibit Canine Distemper Virus-Induced Cell-Cell Fusion but Not Virus-Cell Fusion
TLDR
It is described that an anti-CD9 monoclonal antibody (MAb K41) did not interfere with binding of CDV to cells and uptake of virus, and data indicate that anti- CD9 antibodies selectively block virus-induced cell-cell fusion, whereas virus- cell fusion is not affected. Expand
Improved isolation of rinderpest virus in transformed bovine T lymphoblast cell lines.
TLDR
The lymphoblasts are easy to maintain in culture and since they rapidly recovered 11 isolates from 37 diagnostic samples could prove useful in laboratories carrying out rinderpest diagnosis. Expand
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