The Monro–Kellie hypothesis
@article{Mokri2001TheMH, title={The Monro–Kellie hypothesis}, author={B. Mokri}, journal={Neurology}, year={2001}, volume={56}, pages={1746 - 1748} }
More than two centuries ago, Alexander Monro applied some of the principles of physics to the intracranial contents and for the first time hypothesized that the blood circulating in the cranium was of constant volume at all times. This hypothesis was supported by experiments by Kellie. In its original form, the hypothesis had shortcomings that prompted modification by others. What finally came to be known as the Monro–Kellie doctrine, or hypothesis, is that the sum of volumes of brain, CSF, and… Expand
Topics from this paper
Paper Mentions
Interventional Clinical Trial
The purpose of this Phase IIB randomized controlled trial is to evaluate the safety and
efficacy of CSFD and to provide a preliminary clinical efficacy evaluation of the combination… Expand
Conditions | Spinal Cord Injury |
---|---|
Intervention | Procedure |
503 Citations
Continuous monitoring of the Monro-Kellie doctrine: is it possible?
- Medicine
- Journal of neurotrauma
- 2012
- 33
Non-single quantum MRI : a cardiac modulated rhythm in the brain tissue
- Physics
- 2016
- 5
- Highly Influenced
Intracranial force and cerebrospinal fluid dynamics in brain autoregulation
- Medicine
- 2013 IEEE Jordan Conference on Applied Electrical Engineering and Computing Technologies (AEECT)
- 2013
Normal pressure hydrocephalus as a failure of ICP homeostasis mechanism: the hidden role of Monro–Kellie doctrine in the genesis of NPH
- Medicine
- Child's Nervous System
- 2014
- 3
Cerebral Blood Volume Changes during Brain Activation
- Materials Science, Medicine
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- 2012
- 32
- PDF
References
SHOWING 1-10 OF 15 REFERENCES
Dural enhancement and cerebral displacement secondary to intracranial hypotension
- Medicine
- Neurology
- 1993
- 336
On Disorders of the Cerebral Circulation, and on the Connection between Affections of the Brain and Diseases of the Heart
- The Medico-Chirurgical Review
- 1846
- 16
- PDF
Pathological and Practical Researches on Diseases of the Brain and the Spinal Cord
- Medicine
- The London Medical and Physical Journal
- 1828
- 105
- PDF
Middle cerebral artery pial territory infarcts: A study of the lausanne stroke registry
- Medicine
- Annals of neurology
- 1989
- 65
Hypothesis: impaired clearance is an important link (washout) between hypoperfusion, embolism, and ischemic stroke
- Arch Neurol
- 1998
Some lessons learned about the diagnosis and treatment of spontaneous intracranial hypotension.
- Medicine
- AJNR. American journal of neuroradiology
- 1998
- 55
Doctors Monro: a medical saga. London: The Wellcome Historical Medical Library
- 1964