The Monro–Kellie hypothesis

@article{Mokri2001TheMH,
  title={The Monro–Kellie hypothesis},
  author={Bahram Mokri},
  journal={Neurology},
  year={2001},
  volume={56},
  pages={1746 - 1748}
}
  • B. Mokri
  • Published 26 June 2001
  • Medicine
  • Neurology
More than two centuries ago, Alexander Monro applied some of the principles of physics to the intracranial contents and for the first time hypothesized that the blood circulating in the cranium was of constant volume at all times. This hypothesis was supported by experiments by Kellie. In its original form, the hypothesis had shortcomings that prompted modification by others. What finally came to be known as the Monro–Kellie doctrine, or hypothesis, is that the sum of volumes of brain, CSF, and… 
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