The Mongolian gerbil in experimental epilepsy

  title={The Mongolian gerbil in experimental epilepsy},
  author={Rosalia Bertorelli and Marina Adami and Ennio Ongini},
  journal={The Italian Journal of Neurological Sciences},
The Mongolian gerbil is recognized as a suitable experimental model for studying epileptiform seizures. About 10–20% of the gerbils provided by animal breeders show convulsions when placed in a new laboratory environment or handled for drug administration. In this review, the usefulness of the gerbil is critically evaluated on the basis of the literature available and our experience. Since gerbils often react with seizures in response to external stimuli we utilized a blast of compressed air… Expand
Genetically epilepsy-prone rats (GEPRs) and DBA/2 mice: Two animal models of audiogenic reflex epilepsy for the evaluation of new generation AEDs
This review summarizes the current knowledge about DBA/2 mice and genetically epilepsy-prone rats (GEPRs) and discusses the contribution of such animal models on the investigation of possible newExpand
Intraspecific Allometric comparison of Laboratory gerbils with Mongolian Gerbils Trapped in the Wild Indicates Domestication in Meriones unguiculatus (Milne-Edwards, 1867) (Rodentia: Gerbillinae)
A genetic bottleneck that occurred in 1954 and remarkably smaller brains in LAB indicate that the laboratory strain has become domesticated and should be designated as “Laboratory gerbils” (M. unguiculatus forma domestica) to signify this new case of domestication among rodents. Expand
Critical review of the animal models of generalized epilepsies
  • R. Fariello
  • Medicine
  • The Italian Journal of Neurological Sciences
  • 2005
The state of the art for models of generalized seizures in animals is satisfactory, but improvable for what concerns primary generalized seizures of Petit-Mal type. Other models of secondaryExpand
Catalogue of the behaviour of Meriones unguiculatus f. dom. (Mongolian gerbil) and wild conspecies, in captivity and under natural conditions, based on a systematic literature review
This catalogue of the behaviour of Mongolian gerbil and wild conspecies, in captivity and under natural conditions, is developed by adapting methodology currently widely accepted for conducting and reporting systematic literature reviews, and 116 behavioural traits were compiled and classified. Expand
De novo assembly of the Mongolian gerbil genome and transcriptome
Sequencing of this genome increases the utility of the gerbil as a model organism, opening the availability of now widely used genetic tools. Expand
From bench to drug: Human seizure modeling using Drosophila
The epilepsy phenotype of Drosophila seizure-sensitive mutants is reviewed, a novel class of genes called seizure-suppressors are described, and an unexpected class of anti-epileptic drugs has been identified. Expand
Nigari administration appeared to reduce retention numbers and enhance exercise performance in gerbils. Expand
Indispensable Amino Acid-Deficient Diets Induce Seizures in Ketogenic Diet-Fed Rodents, Demonstrating a Role for Amino Acid Balance in Dietary Treatments for Epilepsy.
Seizure severity in rats and gerbils was reduced after KDs and exacerbated by ThrDev, both in KD- and CD-fed animals, consistent with the mechanistic studies. Expand
Ultrasonic vocalization of pup and adult fat-tailed gerbils (Pachyuromys duprasi)
Pup USV syllables were overall longer and higher-frequency than adult ones, reminiscent of the USV ontogenetic pathway of bats and distinctive to rats and mice, which means that software developed for automated classifying of mice ultrasound might be easily adapted or re-tuned to gerbil USV calls. Expand
The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive effects
Hispidulin markedly reduced the number of animals suffering from seizures after 7 days of treatment and permeability across the blood–brain barrier for the chemically synthesized, 14C‐labelled hispidulin was confirmed by a rat in situ perfusion model. Expand


Spontaneous seizures in the Mongolian gerbil
Approximately 50% of the Mongolian gerbils in our colony were observed to display an epileptiform seizure when placed in a novel area. Forty-six percent of the susceptible animals were descended fromExpand
Spontaneous seizures in the Mongolian gerbil (Meriones unguiculatus)
Approximately 50% of the Mongolian gerbils in our colony were observed to display an epileptiform seizure when placed in a novel area. Forty-six percent of the susceptible animals were descended fromExpand
Value of Mongolian Gerbils in Antiepileptic Drug Evaluation
The results indicate that handling gerbils has a powerful inhibitory effect on seizure susceptibility, which may be useful in studying drug effects on electrophysiological aspects of seizures and as a model for the study of nonpharmacological control of seizures. Expand
Evaluation of anticonvulsant drugs in gerbils with reflex epilepsy.
Comparison of pharmacokinetics of common antiepileptic drugs showed that these drugs, except phenobarbital, were rapidly eliminated by the gerbil which, in this respect, resembled the mouse. Expand
The Gerbil as a Model for the Study of the Epilepsies
A new strain of selectively bred seizure‐sensitive Mongolian gerbils exhibit stereotyped seizures in response to increased stimulus input that can be rated on a seven‐point scale of severity. Expand
Brain amines and spontaneous epileptic seizures in the Mongolian gerbil
Data indicate that a search for differences in regional levels, or turnover rates, of these amines between seizure sensitive and seizure resistant strains of gerbils might be profitable in determining the genetic deficit underlying the seizure phenomenon in these animals. Expand
The Mongolian gerbil (Meriones unguiculatus) as a model for the study of the epilepsies: EEG records of seizures.
  • W. Loskota, P. Lomax
  • Psychology, Medicine
  • Electroencephalography and clinical neurophysiology
  • 1975
EEG recordings from freely moving, seizure sensitive gerbils during seizures of varying severity strengthen the suggestion that selectively bred epileptic strains of Meriones unguiculatus may be a suitable animal model for the study of the epilepsy. Expand
Epilepsy and behaviour of the Mongolian gerbil: An ethological study
Ethological procedures were used to compare behaviour characterizing seizure-sensitive and seizure-resistant gerbils and to examine motor components of their major convulsions and it is suggested that observational studies in epilepsy may contribute to the understanding of the underlying pathophysiological processes. Expand
Neuropharmacological analysis of handling-induced seizures in gerbils
The results indicate that complex interactions between non-specific behavioral and pharmacological factors may limit the reliability of this model. Expand
Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behavior in the Mongolian gerbil.
  • W. Löscher
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1985
Comparison of anticonvulsant potencies of the various drugs in gerbils with potencies reported in other genetic animal models of epilepsy indicated that drugs that increase GABA and dopamine levels in the brain are strikingly more effective in Gerbils than in other species in blocking generalized seizures. Expand