The Molecular Perspective: DNA Topoisomerases

  title={The Molecular Perspective: DNA Topoisomerases},
  author={David S. Goodsell},
  journal={STEM CELLS},
STEM CELLS 2002;20:470-471 Each cell in your body contains about two meters of DNA, all bundled into a space a million times smaller. As you might imagine, this causes significant problems when cells manipulate their DNA, while accessing the genomic information and when dividing the DNA into two portions during cell division. To make things even more complicated, the DNA is a double helix, so it must be unwound to access its information. If you have ever tried to unravel the… 
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    Nature Reviews Molecular Cell Biology
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