The Molecular Perspective: DNA Topoisomerases

  title={The Molecular Perspective: DNA Topoisomerases},
  author={D. Goodsell},
  journal={STEM CELLS},
STEM CELLS 2002;20:470-471 Each cell in your body contains about two meters of DNA, all bundled into a space a million times smaller. As you might imagine, this causes significant problems when cells manipulate their DNA, while accessing the genomic information and when dividing the DNA into two portions during cell division. To make things even more complicated, the DNA is a double helix, so it must be unwound to access its information. If you have ever tried to unravel the… Expand
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Cellular roles of DNA topoisomerases: a molecular perspective
  • JAMES C. Wang
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 2002
In this review, the cellular roles of these enzymes are examined from a molecular point of view. Expand
Tumor cell death induced by topoisomerase-targeting drugs.
  • T. Li, L. Liu
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 2001
This review focuses on recent findings concerning the molecular mechanisms of the stress responses to topoisomerase-mediated DNA damage and the involvement of ubiquitin/26S proteasome and SUMO/UBC9 in these processes. Expand