The Molecular Perspective: DNA Topoisomerases

  title={The Molecular Perspective: DNA Topoisomerases},
  author={D. Goodsell},
  journal={STEM CELLS},
  • D. Goodsell
  • Published 2002
  • Biology, Medicine
  • STEM CELLS 2002;20:470-471 Each cell in your body contains about two meters of DNA, all bundled into a space a million times smaller. As you might imagine, this causes significant problems when cells manipulate their DNA, while accessing the genomic information and when dividing the DNA into two portions during cell division. To make things even more complicated, the DNA is a double helix, so it must be unwound to access its information. If you have ever tried to unravel the… CONTINUE READING
    6 Citations
    Topoisomerase as target for antibacterial and anticancer drug discovery
    • 46
    DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer
    • 7
    Compensatory Evolution in Quinolone Resistant Escherichia coli
    • PDF
    Improved drug carriage and protective potential against Cisplatin-induced toxicity using Boldine-loaded PLGA nanoparticles
    • 3


    Cellular roles of DNA topoisomerases: a molecular perspective
    • J. Wang
    • Biology, Medicine
    • Nature Reviews Molecular Cell Biology
    • 2002
    • 1,963
    • PDF
    Tumor cell death induced by topoisomerase-targeting drugs.
    • T. Li, L. Liu
    • Biology, Medicine
    • Annual review of pharmacology and toxicology
    • 2001
    • 458