The Molecular Motor Toolbox for Intracellular Transport

@article{Vale2003TheMM,
  title={The Molecular Motor Toolbox for Intracellular Transport},
  author={Ronald D. Vale},
  journal={Cell},
  year={2003},
  volume={112},
  pages={467-480}
}
  • R. Vale
  • Published 21 February 2003
  • Biology, Medicine
  • Cell
Eukaryotic cells create internal order by using protein motors to transport molecules and organelles along cytoskeletal tracks. Recent genomic and functional studies suggest that five cargo-carrying motors emerged in primitive eukaryotes and have been widely used throughout evolution. The complexity of these "Toolbox" motors expanded in higher eukaryotes through gene duplication, alternative splicing, and the addition of associated subunits, which enabled new cargoes to be transported… Expand

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References

SHOWING 1-10 OF 225 REFERENCES
Analysis of the myosins encoded in the recently completed Arabidopsis thaliana genome sequence
TLDR
The number of myosins is small overall in Arabidopsis compared with the other sequenced eukaryotic genomes, and exon/intron data suggest that the myosin are highly conserved and that some may be a result of gene duplication. Expand
Kinesin and dynein superfamily proteins and the mechanism of organelle transport.
TLDR
This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins. Expand
Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum
TLDR
The known kinesin and dynein genes in Dictyostelium are described and how the biological functions of these motors has been dissected through a combination of biochemical to genetic approaches are described. Expand
The way things move: looking under the hood of molecular motor proteins.
TLDR
The microtubule-based kinesin motors and actin-based myosin motors generate motions associated with intracellular trafficking, cell division, and muscle contraction using a common core structure and convert energy from adenosine triphosphate into protein motion using a similar conformational change strategy. Expand
The design plan of kinesin motors.
TLDR
Structural features common to all kinesin motors, as well as specialized features that enable subfamilies of related motors to carry out specialized activities, are discussed. Expand
Kinesins in the Arabidopsis genome: A comparative analysis among eukaryotes
TLDR
There are groups of Arabidopsis kinesins that are not present in yeast, Caenorhabditis elegans and Drosophila melanogaster that may, therefore, represent new subfamilies specific to plants and provide clues about their functions in cellular processes. Expand
Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans
TLDR
It is suggested that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubules along with other membrane-bounded organelles are transported normally. Expand
The dynein microtubule motor.
  • S. King
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2000
TLDR
Insight is revealed into the roles played by these various components and the mechanisms of dynein-based motility, including redox-sensitive vicinal dithiols and Ca(2+)-binding, suggesting that the activity of individual dyneins may be subject to multiple regulatory inputs. Expand
Reconstitution of Membrane Transport Powered by a Novel Dimeric Kinesin Motor of the Unc104/Kif1a Family Purified from Dictyostelium
TLDR
Two polypeptides from Dictyostelium extracts are purified and found to be kinesin motors, and the 245-kD protein (DdUnc104) is a close relative of Caenorhabditis elegans Unc104 and mouse KIF1A, neuron-specific motors that deliver synaptic vesicle precursors to nerve terminals. Expand
Dyneins Motor on in Plants
  • S. King
  • Biology, Medicine
  • Traffic
  • 2002
A recent report based on analysis of the Arabidopsis genome suggested that angiosperms do not contain the dynein microtubule motor. However, examination of the whole genome shotgun sequence for riceExpand
...
1
2
3
4
5
...