The Molecular Mechanisms of Allosteric Mutations Impairing MepR Repressor Function in Multidrug-Resistant Strains of Staphylococcus aureus

@inproceedings{Birukou2013TheMM,
  title={The Molecular Mechanisms of Allosteric Mutations Impairing MepR Repressor Function in Multidrug-Resistant Strains of Staphylococcus aureus},
  author={Ivan Birukou and Nam Ky Tonthat and Susan M. Seo and Bryan D. Schindler and Glenn W Kaatz and Richard G Brennan},
  booktitle={mBio},
  year={2013}
}
UNLABELLED Overexpression of the Staphylococcus aureus multidrug efflux pump MepA confers resistance to a wide variety of antimicrobials. mepA expression is controlled by MarR family member MepR, which represses mepA and autorepresses its own production. Mutations in mepR are a primary cause of mepA overexpression in clinical isolates of multidrug-resistant S. aureus. Here, we report crystal structures of three multidrug-resistant MepR variants, which contain the single-amino-acid substitution… CONTINUE READING

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