The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

Abstract

Ser/thr phosphatases dephosphorylate their targets with high specificity, yet the structural and sequence determinants of phosphosite recognition are poorly understood. Calcineurin (CN) is a conserved Ca(2+)/calmodulin-dependent ser/thr phosphatase and the target of immunosuppressants, FK506 and cyclosporin A (CSA). To investigate CN substrate recognition… (More)
DOI: 10.1371/journal.pbio.1001492

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