The Molecular Clock of Neutral Evolution Can Be Accelerated or Slowed by Asymmetric Spatial Structure

@article{Allen2015TheMC,
  title={The Molecular Clock of Neutral Evolution Can Be Accelerated or Slowed by Asymmetric Spatial Structure},
  author={Benjamin Allen and Christine Sample and Yulia Dementieva and Ruben C. Medeiros and Christopher Paoletti and Martin A. Nowak},
  journal={PLoS Computational Biology},
  year={2015},
  volume={11}
}
  • Benjamin Allen, Christine Sample, +3 authors Martin A. Nowak
  • Published 2015
  • Biology, Computer Science, Medicine
  • PLoS Computational Biology
  • Over time, a population acquires neutral genetic substitutions as a consequence of random drift. A famous result in population genetics asserts that the rate, K, at which these substitutions accumulate in the population coincides with the mutation rate, u, at which they arise in individuals: K = u. This identity enables genetic sequence data to be used as a “molecular clock” to estimate the timing of evolutionary events. While the molecular clock is known to be perturbed by selection, it is… CONTINUE READING

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