The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

Abstract

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle. The checkpoint prevents mitotic cells from exiting mitosis in the presence of unattached or improperly attached chromosomes, thus avoiding whole-chromosome gains or losses and their… (More)
DOI: 10.1016/j.cub.2015.10.050

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Cite this paper

@article{Musacchio2015TheMB, title={The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics}, author={Andrea Musacchio}, journal={Current Biology}, year={2015}, volume={25}, pages={R1002-R1018} }