The Mobile FG Nucleoporin Nup98 Is a Cofactor for Crm1-dependent Protein Export

@inproceedings{Oka2010TheMF,
  title={The Mobile FG Nucleoporin Nup98 Is a Cofactor for Crm1-dependent Protein Export},
  author={Masahiro Oka and Munehiro Asally and Yoshinari Yasuda and Yutaka Ogawa and Taro Tachibana and Yoshihiro Yoneda},
  booktitle={Molecular biology of the cell},
  year={2010}
}
Nup98 is a mobile nucleoporin that forms distinct dots in the nucleus, and, although a role for Nup98 in nuclear transport has been suggested, its precise function remains unclear. Here, we show that Nup98 plays an important role in Crm1-mediated nuclear protein export. Nuclear, but not cytoplasmic, dots of EGFP-tagged Nup98 disappeared rapidly after cell treatment with leptomycin B, a specific inhibitor of the nuclear export receptor, Crm1. Mutational analysis demonstrated that Nup98… CONTINUE READING

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