The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology

  title={The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology},
  author={Giorgio Lenaz},
  journal={IUBMB Life},
  • G. Lenaz
  • Published 2001
  • Biology, Medicine
  • IUBMB Life
Mitochondria are major sources of reactive oxygen species (ROS); the main sites of superoxide radical production in the respiratory chain are Complexes III and I; however, other mitochondrial enzymes, such as Complex II, glycerol‐1‐phosphate dehydrogenase, and dihydroorotate dehydrogenase, are also involved in production of ROS. ROS appear to be released both in the matrix and in the intermembrane space; however, their appearance outside the mitochondria may not be physiologically relevant. ROS… Expand
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  • Chemistry, Medicine
  • The Journal of physiology
  • 2003
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