The Missing Sense Modality: The Immune System

@article{Bedford2011TheMS,
  title={The Missing Sense Modality: The Immune System},
  author={Felice L. Bedford},
  journal={Perception},
  year={2011},
  volume={40},
  pages={1265 - 1267}
}
  • F. Bedford
  • Published 1 October 2011
  • Philosophy
  • Perception
The five senses were handed down by Aristotle. I argue that it has only taken two millennia to recognize that the immune system has been the hidden sensory modality. The immune system completes the range of operation allowing detection of meaningful entities at all distances, from very near to very far. It also withstands the often implicit criteria for being a sense modality. Finally, cross-modal interactions between the immune system and vision and other sense modalities should be possible… 
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References

SHOWING 1-8 OF 8 REFERENCES
Genomic Analysis of the Olfactory Receptor Region of the Mouse and Human T-Cell Receptor α/δ Loci
TLDR
A comparative genomic analysis of the mouse and human OR clusters that are found 5′ to the TCR genes in both species is provided and reveals no strong sequence conservation, TATA-boxes, or conserved transcription initiator sites in OR promoter regions.
Separate visual representations for perception and for visually guided behavior
Converging evidence from several sources indicates that two distinct representations of visual space mediate perception and visually guided behavior, respectively. The two maps of visual space follow
The immune system as a sensory organ.
  • J. Blalock
  • Biology, Medicine
    Journal of immunology
  • 1984
La neuro-immuno-endocrinologie est supposee depuis longtemps. En effet, le systeme nerveux innerve les organes et tissus varies du systeme immunitaire et leur stimulation a des effets sur la reponse
Cytokine-induced sickness behavior
Gustatory and extragustatory functions of mammalian taste receptors
`̀ Cytokine-induced sickness behavior'' Brain, Behavior, and Immunity
  • Suppl I,
  • 2003
A perception theory in mind-body medicine: guided visual imagery and mindfulness meditation as cross-modal adaptation'' Psychonomic Bulletin and Review advance online publication available at
    Touch'', in Handbook of Psychology: Experimental Psychology Eds I
    • 2003