The Minute Virus of Mice NS2 proteins are not essential for productive infection of embryonic murine cells in utero.

@article{Tal2014TheMV,
  title={The Minute Virus of Mice NS2 proteins are not essential for productive infection of embryonic murine cells in utero.},
  author={Saar Tal and Michal Mincberg and Irina Rostovsky and Jean Rommelaere and Nathali Salome and Claytus J Davis},
  journal={Virology},
  year={2014},
  volume={468-470},
  pages={
          631-636
        }
}
The P4 promoter of the autonomous parvovirus Minute Virus of Mice (MVM) drives the production of its non-structural proteins, NS1 and NS2. The NS2 isoforms are without enzymatic activity but interact with cellular proteins. While NS2 is crucial to the viral life cycle in cultured murine cells, NS2-null mutant virus productively infects transformed host cells of other species. In the mouse, sensitivity to MVM infection is age dependent, exhibiting limited subclinical infections in adults, but… CONTINUE READING
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