Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs
- BiologyInternational journal of molecular sciences
Ion channels are macromolecular complexes present in the plasma membrane and intracellular organelles of cells. Dysfunction of ion channels results in a group of disorders named channelopathies,…
Biology of the KCNQ1 Potassium Channel
The author discusses the unique functional properties, regulation, cell biology, diverse physiological roles, and involvement in human disease states of this chameleonic K+ channel.
KCNE2 and the K+ channel
The modus operandi and physiological roles of this potent regulator of membrane excitability and ion secretion are reviewed with particular emphasis on the ability of KCNE2 to shape the electrophysiological landscape of both excitable and non-excitable cells.
Impact of ancillary subunits on ventricular repolarization.
- BiologyJournal of electrocardiology
Glycosylation, Assembly and Trafficking of Cardiac Potassium Channel Complexes: A Dissertation
The data suggest that the errant E1 trafficking observed in human embryonic kidney cells may be due, in part, to the presence of endogenous voltage-gated K channels in these cells.
KCNQs: Ligand- and Voltage-Gated Potassium Channels
- BiologyFrontiers in Physiology
The focus of this review is regulation of KCNQs by direct binding of neurotransmitters and metabolites from both animals and plants and the role of the latter in the effects of plants consumed for food and as traditional folk medicines.
Functional Implications of KCNE Subunit Expression for the Kv7.5 (KCNQ5) Channel
- BiologyCellular Physiology and Biochemistry
The results have physiological relevance since Kv7.5 is abundant in skeletal and smooth muscle and its association with KCNE peptides may fine-tune cellular responses.
The KCNQ1 potassium channel: from gene to physiological function.
The current knowledge about the KCNQ1 channel is reviewed with a major focus on interacting proteins and physiological functions, capable of modulating the properties of the channel complexes.
Small Molecule Investigation of KCNQ Potassium Channels: A Dissertation
A model places calmodulin close to the gate ofKCNQ channels, providing structural insight into how CaM is able to communicate changes in intracellular calcium levels to KCNQ channel complexes.
Molecular mechanisms underlying KVS-1-MPS-1 complex assembly.
- BiologyBiophysical journal
The principles that determine the interactions of Caenorhabditis elegans MPS-1, a bifunctional beta-subunit that possesses kinase activity, with Kv channels are investigated.
SHOWING 1-10 OF 190 REFERENCES
Modulation of A-type potassium channels by a family of calcium sensors
Three Kv channel-interacting proteins (KChIPs) that bind to the cytoplasmic amino termini of Kv4 α-subunits are described that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
A minK–HERG complex regulates the cardiac potassium current IKr
It is shown that HERG and minK form a stable complex, and that this heteromultimerization regulates IKr activity, which is central to the control of the heart rate and rhythm.
Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel
KVLQT1 is the subunit that coassembles with minK to form IKS channels and IKS dysfunction is a cause of cardiac arrhythmia, and is shown to encode a K+ channel with biophysical properties unlike other known cardiac currents.
βSubunits Promote K+ Channel Surface Expression through Effects Early in Biosynthesis
MinK-Related Peptide 1 Associates With Kv4.2 and Modulates Its Gating Function: Potential Role as &bgr; Subunit of Cardiac Transient Outward Channel?
- BiologyCirculation research
The data suggest that MiRP1 may serve as a regulatory subunit of Ito channels in the heart, supported by the observation thatMiRP1 induced an “overshoot” of Kv4.2 current amplitude during channel recovery from inactivation, similar to the overshoot of Ita described for human epicardial myocytes.
Do all voltage-gated potassium channels use MiRPs?
- BiologyCirculation research
It is shown that MiRP1 can alter the function of Kv4 family subunits (which contribute to I to, transient outward currents in heart and brain) when they are expressed together in Xenopus oocytes.
MiRP2 Forms Potassium Channels in Skeletal Muscle with Kv3.4 and Is Associated with Periodic Paralysis
A constitutively open potassium channel formed by KCNQ1 and KCNE3
It is shown that the novel β-subunit KCNE3 markedly changes KCNQ1 properties to yield currents that are nearly instantaneous and depend linearly on voltage, which indicates that these proteins may assemble to form the potassium channel that is important for cyclic AMP-stimulated intestinal chloride secretion and that is involved in secretory diarrhoea and cystic fibrosis.
A Single Transmembrane Site in the KCNE-encoded Proteins Controls the Specificity of KvLQT1 Channel Gating*
- BiologyThe Journal of Biological Chemistry
A model of KCNE-potassium channel interaction where the functional consequence depends on the precise contact at a single amino acid is proposed, suggesting that KCNE3 traps the channel in a stable open state.
KCNQ potassium channels: physiology, pathophysiology, and pharmacology.
- BiologyPharmacology & therapeutics