The Microprocessor complex mediates the genesis of microRNAs

@article{Gregory2004TheMC,
  title={The Microprocessor complex mediates the genesis of microRNAs},
  author={Richard I. Gregory and Kai-ping Yan and Govindasamy Amuthan and Thimmaiah P. Chendrimada and Behzad Doratotaj and Neil Cooch and Ramin Shiekhattar},
  journal={Nature},
  year={2004},
  volume={432},
  pages={235-240}
}
MicroRNAs (miRNAs) are a growing family of small non-protein-coding regulatory genes that regulate the expression of homologous target-gene transcripts. They have been implicated in the control of cell death and proliferation in flies, haematopoietic lineage differentiation in mammals, neuronal patterning in nematodes and leaf and flower development in plants. miRNAs are processed by the RNA-mediated interference machinery. Drosha is an RNase III enzyme that was recently implicated in miRNA… 
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