The Microcystic, Elongated, and Fragmented (MELF) Pattern of Invasion: A Single Institution Report of 464 Consecutive FIGO Grade 1 Endometrial Endometrioid Adenocarcinomas.

@article{JoehlinPrice2017TheME,
  title={The Microcystic, Elongated, and Fragmented (MELF) Pattern of Invasion: A Single Institution Report of 464 Consecutive FIGO Grade 1 Endometrial Endometrioid Adenocarcinomas.},
  author={Amy Joehlin-Price and Kelsey E McHugh and Julie A Stephens and Zaibo Li and Floor J. Backes and David E. Cohn and David William Cohen and A. J. Alvarez-Morujo Su{\'a}rez},
  journal={The American journal of surgical pathology},
  year={2017},
  volume={41 1},
  pages={
          49-55
        }
}
MELF invasion has been associated with nonvaginal recurrences and lymph node (LN) metastases in multi-institutional case control studies but has not been well examined in large single-institution cohorts. Hysterectomy specimens with FIGO 1 endometrioid endometrial carcinoma and lymphadenectomies from 2007 to 2012 were identified. Electronic medical records and histologic slides were reviewed. Of 464 identified cases, 163 (35.1%) were noninvasive, 60 (12.9%) had MELF, 222 (47.8%) had a component… CONTINUE READING
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