The Microbial Capsular Polysaccharide Galactoxylomannan Inhibits IL-17A Production in Circulating T Cells from Rheumatoid Arthritis Patients

@inproceedings{Pericolini2013TheMC,
  title={The Microbial Capsular Polysaccharide Galactoxylomannan Inhibits IL-17A Production in Circulating T Cells from Rheumatoid Arthritis Patients},
  author={Eva Pericolini and Alessia Alunno and Elena Gabrielli and Eleonora Bartoloni and Elio Cenci and Siew Loong Chow and Giovanni Bistoni and Arturo Casadevall and Roberto Gerli and Anna Vecchiarelli},
  booktitle={PloS one},
  year={2013}
}
The persistence of activated T cells in rheumatoid arthritis (RA) synovium may be attributable to increased homing, increased retention or a possible imbalance between cell proliferation and programmed cell death. Induction of apoptosis may represent a potential therapeutic approach. Galactoxylomannan (GalXM) from the opportunistic fungus Cryptococcus neoformans can interact with T cells and induce T-cell apoptosis through the inhibition of CD45 phosphatase activity. The aim of this study was… CONTINUE READING

Similar Papers

Loading similar papers…