The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.

@article{Guerry2007TheMN,
  title={The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.},
  author={Fr{\'e}d{\'e}ric Guerry and C Marti and Yue Zhang and Paolo S. Moroni and Emilie Jaqui{\'e}ry and Fritz M{\"u}ller},
  journal={Developmental biology},
  year={2007},
  volume={306 2},
  pages={469-79}
}
The fate of the vulval cells in Caenorhabditis elegans is specified, at least in part, through a highly conserved RTK/Ras mediated signaling cascade that negatively regulates the activity of the ETS-like transcription factor LIN-1. The Hox gene lin-39 functions downstream of both, the LIN-3/RTK/Ras pathway and LIN-1 and plays a pivotal role in controlling vulva cell competence and induction. Here we show that LET-418, a C. elegans ortholog of the human NuRD component Mi-2, negatively modulates… CONTINUE READING
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