The Meyer―Schuster rearrangement: a new synthetic strategy leading to prostaglandins and their drug analogs, Bimatoprost and Latanoprost

  title={The Meyer―Schuster rearrangement: a new synthetic strategy leading to prostaglandins and their drug analogs, Bimatoprost and Latanoprost},
  author={Giuseppe Zanoni and Alessandro D'alfonso and Alessio Porta and Lazzaro Feliciani and Steven P. Nolan and Giovanni Vidari},
Abstract Gold(I) mediated Meyer–Schuster rearrangement for the installation of the ‘lower’ side chain of prostaglandins and their analogs has been developed. This Au-mediated rearrangement, featuring a low catalyst loading and mild reaction conditions, has been demonstrated to be an efficient alternative to the standard Horner–Wadsworth–Emmons reaction in prostaglandin chemistry. Moreover, the present results provide a new synthetic process leading to pharmacologically active prostanoids… 
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