The Methods of Synthesis, Modification, and Biological Activity of 4-Quinolones

  title={The Methods of Synthesis, Modification, and Biological Activity of 4-Quinolones},
  author={Antoaneta Boteva and Olga P. Krasnykh},
New Pharmacokinetic and Microbiological Prediction Equations to Be Used as Models for the Search of Antibacterial Drugs
The obtained results clearly reveal that the combination of molecular topology methods and MLR provides an excellent tool for the prediction of pharmacokinetic properties and microbiological activities in both new and existing compounds with different pharmacological activities.
Antibacterial and Urease Inhibitory activity of New Piperazinyl N-4 Functionalized Ciprofloxacin-oxadiazoles
This research includes design of new ciprofloxacin bearing oxadiazole at the N-4 piperazinyl for the purpose of having urease inhibitory activity as well as antibacterial activity and the docked compounds exhibited better binding to ure enzyme of H. pylori than standard, AHA.
Ciprofloxacin metal complexes and their biological activities: A review
Ciprofloxacin is a derivative of quinolone. Quinolones possesses antibacterial activity and they are structurally related to Nalidixic acid. Various modification has been done in quinolone moiety to
An efficient reduction of azide to amine: a new methodology to synthesize ethyl 7-amino-1-ethyl-6,8-difluoroquinolone-3-carboxylate and its spectroscopic characterization
FT-IR and H1 NMR spectra of the final product, ethyl 7-amino-1-ethyl-6,8-difluoroquinolone-3-carboxylate, suggests the formation of dimers, a feature already observed in norfloxacin.
Fluoroquinolones: Synthesis and Application
The data on 6-fluorо-1,4-dihydroquinolin-4-oxo-3-carboxylic acids and their structural analogues accumulated in the literature for the last 10–15 years are reviewed. Synthetic approaches to the
Synthesis,Characterization &Pharmacological Activities of Substituted-2-Methyl-7-Substituted-Sulphonomides /Azo/Schiff’s Bases/-N-Phenylthiourea-4-Quinolones
The synthesis and pharmacological activities of substituted -2-Methyl-7-substitutedsulphonomides-4-quinolones (2a-m), substituted -2-Methyl-7-substitutedazo -4-quinolones (3am), substituted
Antituberculosis Drug Research: A Critical Overview
This review article critically analyze the antitubercular potential of various classes of compounds, their possibility to be a future drug candidate, and latest information on the clinical status of some novel antitubcular compounds.
Novel derivatives of 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazine-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid: their synthesis, antimicrobial, antifungal, and urease inhibitory studies
Three derivatives of SPFX were synthesized by reacting different aromatic carboxylic acids with SPFX, and 2 was more potent antimicrobial agents than the parent drug as well other fluoroquinolones.
Synthesis and Biological Activities of Selected Quinolone-Metal Complexes
In this review article, synthesis and biological activity of metal complexes of selected 4-quinolones such as norfloxacin, ciprofloxAcin, enrofloxin, gatifloxacIn, and sparfloxACin are presented and discussed.
Microbial transformations of antimicrobial quinolones and related drugs
The quinolones are an important group of synthetic antimicrobial drugs used for treating bacterial diseases of humans and animals and the pharmacologically related naphthyridones, pyranoacridones, and cinnolones to a variety of metabolites.


The methods of synthesis, modification, and biological activity of 4-quinolones (review)
Data on methods for the construction of the 4-quinolone skeleton and modification of the substituents around it are reviewed. The “structure–activity” relationships of 4-quinolones are examined with