The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.

@article{Tavares2016TheMT,
  title={The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.},
  author={Clint D. J. Tavares and Kfir Sharabi and John E. Dominy and Yoonjin Lee and Marta Isasa and Jose M Orozco and Mark P. Jedrychowski and Theodore M Kamenecka and Patrick R. Griffin and Steven P Gygi and Pere B. Puigserver},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 20},
  pages={10635-45}
}
Methionine is an essential sulfur amino acid that is engaged in key cellular functions such as protein synthesis and is a precursor for critical metabolites involved in maintaining cellular homeostasis. In mammals, in response to nutrient conditions, the liver plays a significant role in regulating methionine concentrations by altering its flux through the… CONTINUE READING