The Metastasis Cascade

@article{Klein2008TheMC,
  title={The Metastasis Cascade},
  author={Christoph A. Klein},
  journal={Science},
  year={2008},
  volume={321},
  pages={1785 - 1787}
}
  • C. Klein
  • Published 26 September 2008
  • Education
  • Science
, 1785 (2008); 321 Science Christoph A. Klein The Metastasis Cascade This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): April 30, 2014 www.sciencemag.org (this information is current as of The following resources related… 
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References

SHOWING 1-9 OF 9 REFERENCES
Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies.
TLDR
In a first approach toward immunotherapy, it is demonstrated in 3 patients that infused monoclonal antibody 17-1A can label single tumor cells in bone marrow in vivo and used to follow up 7 patients undergoing 17- 1A therapy in an adjuvant clinical trial.
Metastasis: Dissemination and growth of cancer cells in metastatic sites
TLDR
Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung
TLDR
Untransformed mouse mammary cells that have been engineered to express the inducible oncogenic transgenes MYC and KrasD12 and introduced into the systemic circulation of a mouse can develop into metastatic pulmonary lesions upon immediate or delayed oncogene induction.
Metastasis genes: A progression puzzle
The prevailing model of tumour progression carries with it a striking conceptual inconsistency.
Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts.
TLDR
The technique of peritoneovenous shunting, which returns the fluid to the circulation via a one-way, valved, anastomosis between the peritoneum and the jugular vein, has unrivaled power and interest for those seeking to understand mechanisms underlying tumor metastasis in humans.