The Metastasis Cascade

  title={The Metastasis Cascade},
  author={Christoph A. Klein},
  pages={1785 - 1787}
  • C. Klein
  • Published 26 September 2008
  • Education
  • Science
, 1785 (2008); 321 Science Christoph A. Klein The Metastasis Cascade This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): April 30, 2014 (this information is current as of The following resources related… 
Tumour cell dissemination and growth of metastasis
  • C. Klein
  • Medicine, Biology
    Nature Reviews Cancer
  • 2010
The authors declare that the parallel progression model is incompatible with the cancer stem cell hypothesis, and the link between tumour size and clinically manifest metastasis is not dissemination but colonization.
Circulating and disseminated tumor cells: harbingers or initiators of metastasis?
It is concluded that a greater effort to understand the unique biology of these cells in context will positively impact the ability to use these cells to predict outcome, monitor treatment efficacy, and reveal therapeutically relevant targets to deplete these populations and ultimately prevent metastasis.
Why cancer cells metastasize?
CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers.
Determining Biological Effectors of alpha6 Integrin Cleavage
It is reported here that disassembling actin filaments leads to an increase in α6p production, demonstrating a potential role for actin Filaments to protect α6 integrin from uPA–uPAR induced cleavage via a multi–protein complex.
Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance
Systems biology has emerged as one of the most promising approaches to understand the complexities of tumor-microenvironment interplay on a quantitative multi-scale level, by incorporating genomics, transcriptomics, proteomics, epigenomics and functional genomics studies.
Super competition as a possible mechanism to pioneer precancerous fields.
Current understanding from basic research on cell competition and clinical studies that have analyzed field characteristics to highlight parallels and possible connections are brought together.
Current and emerging concepts in tumour metastasis
New evidence suggests that malignant cells can disseminate at a much earlier stage than previously recognized in tumourigenesis, andGene‐profiling studies support this theory, suggesting that metastatic ability may be an innate property shared by the bulk of cells present early in a developing tumour mass.
Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer
The findings that the cytoskeletal regulator DIAPH3 governs the mesenchymal-amoeboid transition are highlighted, and a new class of tumor-derived microvesicles, large oncosomes, produced by amoeboid cells and with potential clinical utility in prostate and other cancers are identified.


Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies.
In a first approach toward immunotherapy, it is demonstrated in 3 patients that infused monoclonal antibody 17-1A can label single tumor cells in bone marrow in vivo and used to follow up 7 patients undergoing 17- 1A therapy in an adjuvant clinical trial.
Metastasis: Dissemination and growth of cancer cells in metastatic sites
Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung
Untransformed mouse mammary cells that have been engineered to express the inducible oncogenic transgenes MYC and KrasD12 and introduced into the systemic circulation of a mouse can develop into metastatic pulmonary lesions upon immediate or delayed oncogene induction.
Metastasis genes: A progression puzzle
The prevailing model of tumour progression carries with it a striking conceptual inconsistency.
Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts.
The technique of peritoneovenous shunting, which returns the fluid to the circulation via a one-way, valved, anastomosis between the peritoneum and the jugular vein, has unrivaled power and interest for those seeking to understand mechanisms underlying tumor metastasis in humans.