The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation

  title={The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation},
  author={Kiyoshi Nakahara and Masamichi Okada and Shigetada Nakanishi},
  journal={Journal of Neurochemistry},
Abstract: The metabotropic glutamate receptor mGluR5, but not the closely related mGluR1, is expressed in cultured astrocytes, and this expression is up‐regulated by specific growth factors. We investigated the capability and underlying mechanisms of mGluR5 to induce oscillatory responses of intracellular calcium concentration ([Ca2+]i) in cultured rat astrocytes. Single‐cell [Ca2+]i recordings indicated that an mGluR‐selective agonist, (1S,3R)‐1‐aminocyclopentane‐1,3‐dicarboxylate (1S,3R‐ACPD… 
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