The Met-enkephalin analog D-Ala2-Met-enkephalinamide decreases the adrenocortical response to ACTH in dispersed rat adrenal cells.

The effects of the Met-enkephalin analog D-Ala2-Met-enkephalinamide (DALA) on basal and ACTH-stimulated corticosterone secretion from dispersed adrenal cells were investigated. Low doses (10(-10) and 10(-12) M) of DALA resulted in no apparent alteration in the response to ACTH (8 X 10(-9), 3.2 X 10(-8) or 1.6 X 10(-7) M). High doses of DALA (10(-8) and 10… CONTINUE READING