The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit.

@article{Ferracini1995TheMR,
  title={The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit.},
  author={Romano Ferracini and Maria Flavia Di Renzo and Katia Scotlandi and Nicola Baldini and Martina Olivero and Pierluigi Lollini and Ottavio Cremona and Mario Campanacci and Paolo Maria Comoglio},
  journal={Oncogene},
  year={1995},
  volume={10 4},
  pages={739-49}
}
The c-MET oncogene encodes the receptor for the Hepatocyte Growth Factor/Scatter Factor (HGF), a cytokine that stimulates the invasive growth of normal and neoplastic cells. The Met/HGF receptor is expressed by epithelial cells and its ligand by cells of mesenchymal origin. Receptor-ligand interaction occurs via a paracrine circuit. We studied the expression of the Met/HGF receptor and of its ligand in mesenchymal human tumours by examining 39 clinical samples of bone tumours. The Met/HGF… CONTINUE READING

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