The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma

@article{Amber2013TheMC,
  title={The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma},
  author={Kyle T. Amber and Michael Patrick McLeod and Keyvan Nouri},
  journal={Dermatologic Surgery},
  year={2013},
  volume={39},
  pages={232–238}
}
BACKGROUND The discovery of the Merkel cell polyomavirus (MCV) in a large number of Merkel cell carcinomas (MCCs) has led to many investigations into its potential role as an oncovirus. Many studies have recently explored the differences between MCCs infected and not infected with MCV. OBJECTIVE To review the role of MCV in MCC and its potential to influence diagnosis, prognosis, and treatment. METHODS AND MATERIALS An extensive literature search was performed on MCV and its relationship with… 

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References

SHOWING 1-10 OF 72 REFERENCES
Merkel cell polyomavirus in Merkel cell carcinoma of Italian patients
TLDR
Findings indicate a potential role of MCPyV in the pathogenesis of at least a subset of MCCs and suggest it may be involved in clinical samples of Italian patients who were diagnosed MCC.
Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma.
TLDR
Although MCV-positive andMCV-negative MCCs may have different etiologies, these tumors have comparable clinical behaviors and prognosis.
Merkel Cell Polyomavirus Small T Antigen mRNA Level Is Increased following In Vivo UV-Radiation
TLDR
It is demonstrated that solar radiation has an impact on MCPyV mRNA levels that may explain the association between MCC and solar exposure, and is confirmed that small t promoter is indeed UV-inducible.
Quantitation of Human Seroresponsiveness to Merkel Cell Polyomavirus
TLDR
A small pilot animal immunization study revealed that a candidate vaccine based on MCV virus-like particles (VLPs) elicits antibody responses that robustly neutralize MCV reporter vectors in vitro, suggesting that a VLP-based vaccine could be effective for preventing the initial establishment of MCV infection.
Merkel cell carcinoma: recent insights and new treatment options
TLDR
This review summarizes recent findings on MCC pathogenesis with a special emphasis on the impact of MCV, presents an overview of clinical aspects, and discusses treatment options.
Does detection of Merkel cell polyomavirus in Merkel cell carcinoma provide prognostic information?
  • J. Decaprio
  • Medicine, Biology
    Journal of the National Cancer Institute
  • 2009
JNCI | Editorials 905 Awareness of Merkel cell carcinoma (MCC) is increasing within the scientific and medical communities. MCC is a highly lethal skin cancer: Approximately 30% of all MCC patients
Merkel cell polyomavirus infection and Merkel cell carcinoma in HIV-positive individuals
Purpose of review Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinoma (MCC), an aggressive nonmelanoma skin tumour. MCC incidence has been rising in the last decades.
Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma.
TLDR
Findings lend support to the hypothesis that viral infection is frequently associated with the pathogenesis of Merkel cell carcinoma.
Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: an old bond with possible new viral ties.
TLDR
The permissive immunologic environment, which enables the virus-containing tumor cells to survive and proliferate in disorders like CLL, is described, which may constitute the missing link between immunosuppression and the development of MCC.
Distinct Merkel Cell Polyomavirus Molecular Features in Tumour and Non Tumour Specimens from Patients with Merkel Cell Carcinoma
TLDR
It is concluded that MCPyV molecular features in primary MCC tumour and PBMC may help to predict the course of the disease.
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