The Membrane-associated form of the DNA repair protein Ku is involved in cell adhesion to fibronectin.

@article{Monferran2004TheMF,
  title={The Membrane-associated form of the DNA repair protein Ku is involved in cell adhesion to fibronectin.},
  author={Sylvie Monferran and Catherine Muller and Lionel Mourey and Philippe Frit and Bernard Salles},
  journal={Journal of molecular biology},
  year={2004},
  volume={337 3},
  pages={503-11}
}
The Ku heterodimer (Ku70/Ku80) plays a central role in DNA double-strand breaks recognition and repair. However, Ku is expressed also on the surface of different types of cells along with its intracellular pool within the nucleus and the cytoplasm. Participation of membrane-associated Ku in cell-cell interaction has been reported recently. Here, we describe a novel function of cell-surface Ku as an adhesion receptor for fibronectin (Fn). The role of Ku in cell adhesion was investigated by… CONTINUE READING