The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain.

@article{Myers1998TheMP,
  title={The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain.},
  author={Lawrence C. Myers and Claes M Gustafsson and David A. Bushnell and Man. Lui and Hediye Erdjument-Bromage and Paul Tempst and Roger D. Kornberg},
  journal={Genes & development},
  year={1998},
  volume={12 1},
  pages={
          45-54
        }
}
Mediator was resolved from yeast as a multiprotein complex on the basis of its requirement for transcriptional activation in a fully defined system. Three groups of mediator polypeptides could be distinguished: the products of five SRB genes, identified as suppressors of carboxy-terminal domain (CTD)-truncation mutants; products of four genes identified as global repressors; and six members of a new protein family, termed Med, thought to be primarily responsible for transcriptional activation… CONTINUE READING

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