The Mechanism of the Supercoiled DNA Recognition by the Eukaryotic Type I Topoisomerases: I. The Enzyme Interaction with Nonspecific Oligonucleotides

@article{Bugreev2003TheMO,
  title={The Mechanism of the Supercoiled DNA Recognition by the Eukaryotic Type I Topoisomerases: I. The Enzyme Interaction with Nonspecific Oligonucleotides},
  author={Dmitrii V Bugreev and Valentina N Buneva and Olga I Sinitsyna and Georgy A Nevinsky},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2003},
  volume={29},
  pages={143-153}
}
Interaction of the DNA type I topoisomerases from the murine and human placenta cells with nonspecific oligonucleotides was analyzed. The contributions of strong and week nonspecific electrostatic, van der Waals's, and hydrophobic interactions, and hydrogen bonding of the enzymes to the complex formation with the single- and double-stranded DNAs were determined. The factors that determine the top-priority recognition of the topologically stressed DNA were revealed. The results were interpreted… CONTINUE READING

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