The Mechanism of insulin secretion after oral glucose administration

@article{Fischer1972TheMO,
  title={The Mechanism of insulin secretion after oral glucose administration},
  author={Ulrich Fischer and Hendrik Hommel and Marc Zi{\'e}gler and Richard P. Michael},
  journal={Diabetologia},
  year={1972},
  volume={8},
  pages={104-110}
}
In conscious trained dogs (Alsatians) the IRI-concentration in the peripheral venous blood after oral administration of glucose increases when the blood glucose is still unchanged. After one or two peaks during the first 20 min IRI increases parallel to the blood sugar increase. In relation to the intravenous injection of glucose the IRI maximum after oral administration occurs earlier. Furthermore the ratio of the IRI to blood sugar areas is raised. Without any blood sugar change the IRI… CONTINUE READING

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