The Mechanism of Neuroprotection by Topiramate in an Animal Model of Epilepsy

@article{Kudin2004TheMO,
  title={The Mechanism of Neuroprotection by Topiramate in an Animal Model of Epilepsy},
  author={Alexei P. Kudin and Grazyna Debska-Vielhaber and Stefan Vielhaber and Christian Erich Elger and Wolfram S. Kunz},
  journal={Epilepsia},
  year={2004},
  volume={45}
}
Summary:  Purpose: For the antiepileptic drug (AED) topiramate (TPM), neuroprotective effects have been reported in models of focal cerebral ischemia and experimental status epilepticus, but the putative mechanism of action has remained elusive. 
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Purpose: These studies further investigate the ability of topiramate (TPM) to enhance γ‐aminobutyric acid (GABA)‐mediated inhibition through a benzodiazepine‐insensitive pathway.
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TLDR
A hypothesis for the mechanistic basis of the anticonvulsant activity of TPM is presented, which proposes that TPM binds to certain membrane ion channel proteins at phosphory‐lation sites and thereby allosterically modulates channel conductance and secondarily inhibits protein phosphorylation. Expand
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TLDR
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It is suggested that topiramate has a neuroprotective effect against neuronal damage following global ischemia in the gerbils. Expand
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