The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin β Subunit Gene.

@article{Sasaki2018TheMO,
  title={The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin β Subunit Gene.},
  author={Shigekazu Sasaki and Akio Matsushita and Go Kuroda and Hiroko Nakamura and Yutaka Oki and Takafumi Suda},
  journal={Vitamins and hormones},
  year={2018},
  volume={106},
  pages={97-127}
}
Thyroid hormone (T3) activates (positive regulation) or represses (negative regulation) target genes at the transcriptional level. The molecular mechanism of the former has been elucidated in detail; however, the mechanism for negative regulation has not been established. The best example of the gene that is negatively regulated by T3 is the thyrotropin… CONTINUE READING