The Mechanism of Myosin VI Translocation and Its Load-Induced Anchoring

@article{Altman2004TheMO,
  title={The Mechanism of Myosin VI Translocation and Its Load-Induced Anchoring},
  author={David Altman and H.Lee Sweeney and James A Spudich},
  journal={Cell},
  year={2004},
  volume={116},
  pages={737-749}
}
Myosin VI is thought to function as both a transporter and an anchor. While in vitro studies suggest possible mechanisms for processive stepping, a biochemical basis for anchoring has not been demonstrated. Using optical trapping, we observed myosin VI stepping against applied forces. Step size is not strongly affected by such loads. At saturating ATP… CONTINUE READING