The Mechanism of Inhibition of Protein Synthesis by the Proline-Rich Peptide Oncocin

@inproceedings{Roy2015TheMO,
  title={The Mechanism of Inhibition of Protein Synthesis by the Proline-Rich Peptide Oncocin},
  author={Raktim N. Roy and Ivan B. Lomakin and Matthieu G. Gagnon and Thomas A Steitz},
  booktitle={Nature Structural &Molecular Biology},
  year={2015}
}
Antibiotic-resistant bacteria are a global health issue necessitating the development of new effective therapeutics. Proline-rich antimicrobial peptides (PrAMPs), which include oncocins, are an extensively studied class of AMPs that counteract bacterial infection at submicromolar concentrations. Oncocins enter and kill bacteria by inhibiting certain targets rather than by acting through membrane lysis. Although they have recently been reported to bind DnaK and the bacterial ribosome, their mode… CONTINUE READING

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