The Mechanism of Carbamazepine Aggravation of Absence Seizures

  title={The Mechanism of Carbamazepine Aggravation of Absence Seizures},
  author={Lige Liu and Thomas W. Zheng and Margaret J. Morris and Charlott Wallengren and Alison L. Clarke and Christopher A. Reid and Steven Petrou and Terence J. O'Brien},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={790 - 798}
Carbamazepine (CBZ) aggravates many generalized seizures types, particularly absence seizures, but the mechanisms underlying this are poorly understood. GABA signaling within the reticular nucleus (Rt) and the ventrobasal complex (VB) of the thalamus is critical to the neurophysiology of absence seizures. The hypothesis that CBZ aggravates absence seizures by acting at the VB thalamus via a GABAA receptor-mediated mechanism was investigated in a genetic rat model, generalized absence epilepsy… 

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