The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons

@inproceedings{Hillebrand2010TheMD,
  title={The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons},
  author={Jens Hillebrand and Kangyu Pan and Anil Kokaram and Scott A. Barbee and Roy Parker and Mani Ramaswami},
  booktitle={Front. Neural Circuits},
  year={2010}
}
mRNP granules at adult central synapses are postulated to regulate local mRNA translation and synapse plasticity. However, they are very poorly characterized in vivo. Here, in Drosophila olfactory synapses, we present early observations and characterization of candidate synaptic mRNP particles, one of which contains a widely conserved, DEAD-box helicase, Me31B. In Drosophila, Me31B is required for translational repression of maternal and miRNA-target mRNAs. A role in neuronal translational… CONTINUE READING
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Gaussian mixture model for spot analysis in microscopy

  • K. Pan, A. Kokaram, J. Hillebrand, M. Ramaswami
  • Proceedings of the IEEE International Symposium…
  • 2010
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