The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target

@inproceedings{Simon2014TheMR,
  title={The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target},
  author={Nicholas E Simon and Anthony Schwacha},
  booktitle={BioMed research international},
  year={2014}
}
Numerous eukaryotic replication factors have served as chemotherapeutic targets. One replication factor that has largely escaped drug development is the Mcm2-7 replicative helicase. This heterohexameric complex forms the licensing system that assembles the replication machinery at origins during initiation, as well as the catalytic core of the CMG (Cdc45-Mcm2-7-GINS) helicase that unwinds DNA during elongation. Emerging evidence suggests that Mcm2-7 is also part of the replication checkpoint, a… CONTINUE READING
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