The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target

  title={The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target},
  author={Nicholas E Simon and Anthony Schwacha},
  booktitle={BioMed research international},
Numerous eukaryotic replication factors have served as chemotherapeutic targets. One replication factor that has largely escaped drug development is the Mcm2-7 replicative helicase. This heterohexameric complex forms the licensing system that assembles the replication machinery at origins during initiation, as well as the catalytic core of the CMG (Cdc45-Mcm2-7-GINS) helicase that unwinds DNA during elongation. Emerging evidence suggests that Mcm2-7 is also part of the replication checkpoint, a… CONTINUE READING
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TheMcm complex: unwinding the mechanism of a replicative helicase

M. L. Bochman andA. Schwacha
Microbiology and Molecular Biology Reviews, vol. 73, no. 4, pp. 652–683, 2009. • 2009
View 5 Excerpts
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Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 5 Excerpts
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DNA replication in eukaryotic cells.

Annual review of biochemistry • 2002
View 3 Excerpts
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