The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation

@inproceedings{Minkovsky2014TheMP,
  title={The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation},
  author={Alissa Minkovsky and A. J. Sahakyan and Elyse K Rankin-Gee and Giancarlo A. Bonora and Sanjeet G. Patel and Kathrin Plath},
  booktitle={Epigenetics & Chromatin},
  year={2014}
}
BackgroundX chromosome inactivation (XCI) is a developmental program of heterochromatin formation that initiates during early female mammalian embryonic development and is maintained through a lifetime of cell divisions in somatic cells. Despite identification of the crucial long non-coding RNA Xist and involvement of specific chromatin modifiers in the establishment and maintenance of the heterochromatin of the inactive X chromosome (Xi), interference with known pathways only partially… CONTINUE READING
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