The Mauthner Cell Half a Century Later: A Neurobiological Model for Decision-Making?

@article{Korn2005TheMC,
  title={The Mauthner Cell Half a Century Later: A Neurobiological Model for Decision-Making?},
  author={H. Korn and D. Faber},
  journal={Neuron},
  year={2005},
  volume={47},
  pages={13-28}
}
The Mauthner (M) cell is a critical element in a vital escape "reflex" triggered by abrupt or threatening events. Its properties at the molecular and synaptic levels, their various forms of plasticity, and the design of its networks, are all well adapted for this survival function. They guarantee that this behavior is appropriately unilateral, variable, and unpredictable. The M cell sets the behavioral threshold, and, acting in concert with other elements of the brainstem escape network… Expand

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References

SHOWING 1-10 OF 285 REFERENCES
The Mauthner cell and other identified neurons of the brainstem escape network of fish
TLDR
A neuroethological theory of fish escape that accurately reconciled the underlying neural function with a correct concept of the motor act is devised and a set of descriptive equations written in terms of stimulus angle, magnitude and timing variables of trunk muscle contractions, and resulting escape trajectory are discovered. Expand
Role of the Mauthner cell in sensorimotor integration by the brain stem escape network.
TLDR
This work shows that the firing of the Mauthner cell results in a short-latency body contraction that orients the initial stage of the C start away from the direction of the threatening stimulus, and identifies candidate neurons of this network which can be studied at the single-cell level. Expand
Role of medullary networks and postsynaptic membrane properties in regulating Mauthner cell responsiveness to sensory excitation.
TLDR
The frequency-dependent characteristics of inhibition and excitation, as revealed by studies of individual identified synaptic connections, are compared to emphasize the notion that although inhibition is maximized for weak transient stimuli, it becomes depressed at auditory stimulus frequencies that facilitate excitatory transmission and evoke the escape response. Expand
Escape behavior — brainstem and spinal cord circuitry and function
Recent work has demonstrated that the neural circuits mediating escape reactions in lower vertebrates and mammals have a common framework, with only two excitatory central synapses in the reflex arc.Expand
Lateralization and adaptation of a continuously variable behavior following lesions of a reticulospinal command neuron
This study utilizes digitized cinematic data and lesions of individual Mauthner (M-) cells, large medial reticulospinal command neurons, to examine their role in goldfish C-starts elicited byExpand
Alternative neural pathways initiate fast-start responses following lesions of the mauthner neuron in goldfish
TLDR
It is concluded that firing of the M-cell is causally related to the onset of C-type fast-start responses in adult fish, but, when the M -cell is inactivated, alternative neural pathways that coexist with theM-cell can initiate the C- type fast- start behavior pattern. Expand
Central Cellular Mechanisms Underlying Temperature-Dependent Changes in the Goldfish Startle-Escape Behavior
TLDR
The results illustrate that the balance between excitatory and inhibitory influences can determine the expression of a behavior and its modification and at the same time underline the significance of temperature for nervous system function and behavior. Expand
Differential activation of Mauthner and non-Mauthner startle circuits in the zebrafish: Implications for functional substitution
TLDR
It is demonstrated that vibrational stimulation of the tail reliably elicits responses initiated by non-Mauthner circuits in animals with intact M-cells, and at least two sensory systems are involved in the activation of these startle systems when stimulating the head and tail of the zebrafish. Expand
Molecular biology of learning: modulation of transmitter release.
TLDR
This review focuses primarily on short-term sensitization of the gill and siphon reflex in the marine mollusk, Aplysia californica, and analyses of this form of learning provide direct evidence that protein phosphorylation dependent on cyclic adenosine monophosphate can modulate synaptic action. Expand
Activation of Mauthner neurons during prey capture
TLDR
The Mauthner (M-) cells, a bilateral pair of medullary neurons in fish, initiate the characteristic “C-start” predatory escape response of teleosts, and may be considered a part of behaviorally shared neural circuitry. Expand
...
1
2
3
4
5
...