The Mauthner Cell Half a Century Later: A Neurobiological Model for Decision-Making?

@article{Korn2005TheMC,
  title={The Mauthner Cell Half a Century Later: A Neurobiological Model for Decision-Making?},
  author={Henri Korn and Donald S. Faber},
  journal={Neuron},
  year={2005},
  volume={47},
  pages={13-28}
}

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References

SHOWING 1-10 OF 211 REFERENCES

The Mauthner cell and other identified neurons of the brainstem escape network of fish

Role of the Mauthner cell in sensorimotor integration by the brain stem escape network.

TLDR
This work shows that the firing of the Mauthner cell results in a short-latency body contraction that orients the initial stage of the C start away from the direction of the threatening stimulus, and identifies candidate neurons of this network which can be studied at the single-cell level.

Role of medullary networks and postsynaptic membrane properties in regulating Mauthner cell responsiveness to sensory excitation.

TLDR
The frequency-dependent characteristics of inhibition and excitation, as revealed by studies of individual identified synaptic connections, are compared to emphasize the notion that although inhibition is maximized for weak transient stimuli, it becomes depressed at auditory stimulus frequencies that facilitate excitatory transmission and evoke the escape response.

Escape behavior — brainstem and spinal cord circuitry and function

Alternative neural pathways initiate fast-start responses following lesions of the mauthner neuron in goldfish

TLDR
It is concluded that firing of the M-cell is causally related to the onset of C-type fast-start responses in adult fish, but, when the M -cell is inactivated, alternative neural pathways that coexist with theM-cell can initiate the C- type fast- start behavior pattern.

Central Cellular Mechanisms Underlying Temperature-Dependent Changes in the Goldfish Startle-Escape Behavior

TLDR
The results illustrate that the balance between excitatory and inhibitory influences can determine the expression of a behavior and its modification and at the same time underline the significance of temperature for nervous system function and behavior.

Molecular biology of learning: modulation of transmitter release.

TLDR
This review focuses primarily on short-term sensitization of the gill and siphon reflex in the marine mollusk, Aplysia californica, and analyses of this form of learning provide direct evidence that protein phosphorylation dependent on cyclic adenosine monophosphate can modulate synaptic action.

Differential activation of Mauthner and non-Mauthner startle circuits in the zebrafish: Implications for functional substitution

TLDR
It is demonstrated that vibrational stimulation of the tail reliably elicits responses initiated by non-Mauthner circuits in animals with intact M-cells, and at least two sensory systems are involved in the activation of these startle systems when stimulating the head and tail of the zebrafish.

The command neuron concept

TLDR
It is suggested that a command neuron be defined as a neuron that is both necessary and sufficient for the initiation of a given behavior, even though individual neurons of the group fail to meet the criteria.
...